Effective staff interdependence is needed to improve care of older adults in nursing homes. We synthesized research about nursing management practices that help nursing home staff members manage their relationships for better care. We searched PubMed for studies of relationship-oriented management in nursing homes, published in English between 2000 and 2010. We evaluated and synthesized findings from the literature. Thirty-three articles met the inclusion criteria. Analyzing these studies, we identified 3 themes: (a) managing relationships between managers and staff, (b) staff participation in decision-making, and (c) work designs that foster staff interactions. Most studies were descriptive and suggested that relationship-oriented management practices will promote better outcomes. Future intervention research that combines relationship-oriented management and evidenced-based clinical practices will help staff to skillfully manage problems in nursing home care, including complex geriatric syndromes.