Skip to main content
Journal cover image

A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.

Publication ,  Journal Article
Sterman, DH; Mehta, AC; Wood, DE; Mathur, PN; McKenna, RJ; Ost, DE; Truwit, JD; Diaz, P; Wahidi, MM; Cerfolio, R; Maxfield, R; Musani, AI ...
Published in: Respiration
2010

BACKGROUND: Chronic obstructive pulmonary disease (COPD) affects millions of people and has limited treatment options. Surgical treatments for severe COPD with emphysema are effective for highly selected patients. A minimally invasive method for treating emphysema could decrease morbidity and increase acceptance by patients. OBJECTIVE: To study the safety and effectiveness of the IBV(R) Valve for the treatment of severe emphysema. METHODS: A multicenter study treated 91 patients with severe obstruction, hyperinflation and upper lobe (UL)-predominant emphysema with 609 bronchial valves placed bilaterally into ULs. RESULTS: Valves were placed in desired airways with 99.7% technical success and no migration or erosion. There were no procedure-related deaths and 30-day morbidity and mortality were 5.5 and 1.1%, respectively. Pneumothorax was the most frequent serious device-related complication and primarily occurred when all segments of a lobe, especially the left UL, were occluded. Highly significant health-related quality of life (HRQL) improvement (-8.2 +/- 16.2, mean +/- SD change at 6 months) was observed. HRQL improvement was associated with a decreased volume (mean -294 +/- 427 ml, p = 0.007) in the treated lobes without visible atelectasis. FEV(1), exercise tests, and total lung volume were not changed but there was a proportional shift, a redirection of inspired volume to the untreated lobes. Combined with perfusion scan changes, this suggests that there is improved ventilation and perfusion matching in non-UL lung parenchyma. CONCLUSION: Bronchial valve treatment of emphysema has multiple mechanisms of action and acceptable safety, and significantly improves quality of life for the majority of patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Respiration

DOI

EISSN

1423-0356

Publication Date

2010

Volume

79

Issue

3

Start / End Page

222 / 233

Location

Switzerland

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Circulation
  • Prostheses and Implants
  • Prospective Studies
  • Postoperative Complications
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sterman, D. H., Mehta, A. C., Wood, D. E., Mathur, P. N., McKenna, R. J., Ost, D. E., … IBV Valve US Pilot Trial Research Team, . (2010). A multicenter pilot study of a bronchial valve for the treatment of severe emphysema. Respiration, 79(3), 222–233. https://doi.org/10.1159/000259318
Sterman, D. H., A. C. Mehta, D. E. Wood, P. N. Mathur, R. J. McKenna, D. E. Ost, J. D. Truwit, et al. “A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.Respiration 79, no. 3 (2010): 222–33. https://doi.org/10.1159/000259318.
Sterman DH, Mehta AC, Wood DE, Mathur PN, McKenna RJ, Ost DE, et al. A multicenter pilot study of a bronchial valve for the treatment of severe emphysema. Respiration. 2010;79(3):222–33.
Sterman, D. H., et al. “A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.Respiration, vol. 79, no. 3, 2010, pp. 222–33. Pubmed, doi:10.1159/000259318.
Sterman DH, Mehta AC, Wood DE, Mathur PN, McKenna RJ, Ost DE, Truwit JD, Diaz P, Wahidi MM, Cerfolio R, Maxfield R, Musani AI, Gildea T, Sheski F, Machuzak M, Haas AR, Gonzalez HX, Springmeyer SC, IBV Valve US Pilot Trial Research Team. A multicenter pilot study of a bronchial valve for the treatment of severe emphysema. Respiration. 2010;79(3):222–233.
Journal cover image

Published In

Respiration

DOI

EISSN

1423-0356

Publication Date

2010

Volume

79

Issue

3

Start / End Page

222 / 233

Location

Switzerland

Related Subject Headings

  • United States
  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Respiratory System
  • Quality of Life
  • Pulmonary Emphysema
  • Pulmonary Circulation
  • Prostheses and Implants
  • Prospective Studies
  • Postoperative Complications