Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.

Published

Journal Article

Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.

Full Text

Duke Authors

Cited Authors

  • Lachance, DH; Yang, P; Johnson, DR; Decker, PA; Kollmeyer, TM; McCoy, LS; Rice, T; Xiao, Y; Ali-Osman, F; Wang, F; Stoddard, SM; Sprau, DJ; Kosel, ML; Wiencke, JK; Wiemels, JL; Patoka, JS; Davis, F; McCarthy, B; Rynearson, AL; Worra, JB; Fridley, BL; O'Neill, BP; Buckner, JC; Il'yasova, D; Jenkins, RB; Wrensch, MR

Published Date

  • September 2011

Published In

Volume / Issue

  • 174 / 5

Start / End Page

  • 574 - 581

PubMed ID

  • 21742680

Pubmed Central ID

  • 21742680

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

International Standard Serial Number (ISSN)

  • 0002-9262

Digital Object Identifier (DOI)

  • 10.1093/aje/kwr124

Language

  • eng