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Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.

Publication ,  Journal Article
Lachance, DH; Yang, P; Johnson, DR; Decker, PA; Kollmeyer, TM; McCoy, LS; Rice, T; Xiao, Y; Ali-Osman, F; Wang, F; Stoddard, SM; Sprau, DJ ...
Published in: Am J Epidemiol
September 1, 2011

Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.

Duke Scholars

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

September 1, 2011

Volume

174

Issue

5

Start / End Page

574 / 581

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Hypersensitivity
  • Humans
  • Glioblastoma
  • Genetic Predisposition to Disease
  • Female
 

Citation

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Lachance, D. H., Yang, P., Johnson, D. R., Decker, P. A., Kollmeyer, T. M., McCoy, L. S., … Wrensch, M. R. (2011). Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. Am J Epidemiol, 174(5), 574–581. https://doi.org/10.1093/aje/kwr124
Lachance, Daniel H., Ping Yang, Derek R. Johnson, Paul A. Decker, Thomas M. Kollmeyer, Lucie S. McCoy, Terri Rice, et al. “Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.Am J Epidemiol 174, no. 5 (September 1, 2011): 574–81. https://doi.org/10.1093/aje/kwr124.
Lachance DH, Yang P, Johnson DR, Decker PA, Kollmeyer TM, McCoy LS, et al. Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. Am J Epidemiol. 2011 Sep 1;174(5):574–81.
Lachance, Daniel H., et al. “Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.Am J Epidemiol, vol. 174, no. 5, Sept. 2011, pp. 574–81. Pubmed, doi:10.1093/aje/kwr124.
Lachance DH, Yang P, Johnson DR, Decker PA, Kollmeyer TM, McCoy LS, Rice T, Xiao Y, Ali-Osman F, Wang F, Stoddard SM, Sprau DJ, Kosel ML, Wiencke JK, Wiemels JL, Patoka JS, Davis F, McCarthy B, Rynearson AL, Worra JB, Fridley BL, O’Neill BP, Buckner JC, Il’yasova D, Jenkins RB, Wrensch MR. Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. Am J Epidemiol. 2011 Sep 1;174(5):574–581.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

September 1, 2011

Volume

174

Issue

5

Start / End Page

574 / 581

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Hypersensitivity
  • Humans
  • Glioblastoma
  • Genetic Predisposition to Disease
  • Female