COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.

Journal Article (Journal Article)

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

Full Text

Duke Authors

Cited Authors

  • Shashi, V; Howard, TD; Keshavan, MS; Kaczorowski, J; Berry, MN; Schoch, K; Spence, EJ; Kwapil, TR

Published Date

  • July 30, 2010

Published In

Volume / Issue

  • 178 / 2

Start / End Page

  • 433 - 436

PubMed ID

  • 20488547

Pubmed Central ID

  • PMC3645485

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/j.psychres.2010.04.048


  • eng

Conference Location

  • Ireland