COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
Publication
, Journal Article
Shashi, V; Howard, TD; Keshavan, MS; Kaczorowski, J; Berry, MN; Schoch, K; Spence, EJ; Kwapil, TR
Published in: Psychiatry Res
July 30, 2010
The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
Duke Scholars
Published In
Psychiatry Res
DOI
ISSN
0165-1781
Publication Date
July 30, 2010
Volume
178
Issue
2
Start / End Page
433 / 436
Location
Ireland
Related Subject Headings
- Valine
- Psychiatry
- Psychiatric Status Rating Scales
- Polymorphism, Single Nucleotide
- Neuropsychological Tests
- Methionine
- Male
- Humans
- Genotype
- Genetic Predisposition to Disease
Citation
APA
Chicago
ICMJE
MLA
NLM
Shashi, V., Howard, T. D., Keshavan, M. S., Kaczorowski, J., Berry, M. N., Schoch, K., … Kwapil, T. R. (2010). COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. Psychiatry Res, 178(2), 433–436. https://doi.org/10.1016/j.psychres.2010.04.048
Shashi, Vandana, Timothy D. Howard, Matcheri S. Keshavan, Jessica Kaczorowski, Margaret N. Berry, Kelly Schoch, Edward J. Spence, and Thomas R. Kwapil. “COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.” Psychiatry Res 178, no. 2 (July 30, 2010): 433–36. https://doi.org/10.1016/j.psychres.2010.04.048.
Shashi V, Howard TD, Keshavan MS, Kaczorowski J, Berry MN, Schoch K, et al. COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. Psychiatry Res. 2010 Jul 30;178(2):433–6.
Shashi, Vandana, et al. “COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.” Psychiatry Res, vol. 178, no. 2, July 2010, pp. 433–36. Pubmed, doi:10.1016/j.psychres.2010.04.048.
Shashi V, Howard TD, Keshavan MS, Kaczorowski J, Berry MN, Schoch K, Spence EJ, Kwapil TR. COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. Psychiatry Res. 2010 Jul 30;178(2):433–436.
Published In
Psychiatry Res
DOI
ISSN
0165-1781
Publication Date
July 30, 2010
Volume
178
Issue
2
Start / End Page
433 / 436
Location
Ireland
Related Subject Headings
- Valine
- Psychiatry
- Psychiatric Status Rating Scales
- Polymorphism, Single Nucleotide
- Neuropsychological Tests
- Methionine
- Male
- Humans
- Genotype
- Genetic Predisposition to Disease