COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
Shashi, V; Howard, TD; Keshavan, MS; Kaczorowski, J; Berry, MN; Schoch, K; Spence, EJ; Kwapil, TR
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