Synaptic plasticity in drug reward circuitry.

Journal Article (Review;Journal Article)

Drug addiction is a major public health issue worldwide. The persistence of drug craving coupled with the known recruitment of learning and memory centers in the brain has led investigators to hypothesize that the alterations in glutamatergic synaptic efficacy brought on by synaptic plasticity may play key roles in the addiction process. Here we review the present literature, examining the properties of synaptic plasticity within drug reward circuitry, and the effects that drugs of abuse have on these forms of plasticity. Interestingly, multiple forms of synaptic plasticity can be induced at glutamatergic synapses within the dorsal striatum, its ventral extension the nucleus accumbens, and the ventral tegmental area, and at least some of these forms of plasticity are regulated by behaviorally meaningful administration of cocaine and/or amphetamine. Thus, the present data suggest that regulation of synaptic plasticity in reward circuits is a tractable candidate mechanism underlying aspects of addiction.

Full Text

Duke Authors

Cited Authors

  • Winder, DG; Egli, RE; Schramm, NL; Matthews, RT

Published Date

  • November 2002

Published In

Volume / Issue

  • 2 / 7

Start / End Page

  • 667 - 676

PubMed ID

  • 12420805

Electronic International Standard Serial Number (EISSN)

  • 1875-5666

International Standard Serial Number (ISSN)

  • 1566-5240

Digital Object Identifier (DOI)

  • 10.2174/1566524023361961


  • eng