LTP in the mouse nucleus accumbens is developmentally regulated.

Published

Journal Article

Glutamatergic transmission in the nucleus accumbens (NAc) has been shown to be important for behavioral adaptations in response to drugs of abuse. NMDA-receptor dependent long-term potentiation (LTP) of glutamatergic synaptic transmission has been hypothesized to underlie many lasting alterations in behavior. Thus, we examined LTP in NAc core and find that it is developmentally regulated. Specifically, tetanus-evoked, NMDA receptor-dependent LTP is observed in the NAc of "adolescent" (3-week-old) mice more frequently than in adult (6-20-week-old) mice. In contrast, cAMP-dependent enhancement of transmission is not developmentally regulated. Removal of extracellular Mg(2+) restores LTP in adult NAc core, suggesting developmental regulation of induction processes rather than maintenance mechanisms. These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans.

Full Text

Duke Authors

Cited Authors

  • Schramm, NL; Egli, RE; Winder, DG

Published Date

  • September 2002

Published In

Volume / Issue

  • 45 / 4

Start / End Page

  • 213 - 219

PubMed ID

  • 12125042

Pubmed Central ID

  • 12125042

Electronic International Standard Serial Number (EISSN)

  • 1098-2396

International Standard Serial Number (ISSN)

  • 0887-4476

Digital Object Identifier (DOI)

  • 10.1002/syn.10104

Language

  • eng