Seven-transmembrane receptors and ubiquitination.

Journal Article (Journal Article;Review)

Regulation of protein function by posttranslational modification plays an important role in many biological pathways. The most well known among such modifications is protein phosphorylation performed by highly specific protein kinases. In the past decade, however, covalent linkage of the low-molecular-weight protein ubiquitin to substrate proteins (protein ubiquitination) has proven to be yet another widely used mechanism of protein regulation playing a crucial role in virtually all aspects of cellular functions. This review highlights some of the recently discovered and provocative roles for ubiquitination in the regulation of the life cycle and signal transduction properties of 7-transmembrane receptors that serve to integrate many biological functions and play fundamental roles in cardiovascular homeostasis.

Full Text

Duke Authors

Cited Authors

  • Shenoy, SK

Published Date

  • April 27, 2007

Published In

Volume / Issue

  • 100 / 8

Start / End Page

  • 1142 - 1154

PubMed ID

  • 17463329

Pubmed Central ID

  • PMC1952537

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

Digital Object Identifier (DOI)

  • 10.1161/01.RES.0000261939.88744.5a


  • eng

Conference Location

  • United States