Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit.

Journal Article (Journal Article)

OBJECTIVE: The purpose of this study is to examine the results of repeat lumbar puncture in infants with initial positive cerebrospinal fluid (CSF) cultures in order to determine the clinical characteristics and outcomes of infants with repeat positive cultures. STUDY DESIGN: Cohort study of infants with an initial positive CSF culture undergoing repeat lumbar puncture between 1997 and 2004 at 150 neonatal intensive care units managed by the Pediatrix Medical group. We compared the clinical outcomes of infants with repeat positive cultures and infants with repeat negative cultures. RESULT: We identified 118 infants with repeat CSF cultures. Of these, 26 infants had repeat positive cultures. A higher proportion with repeat positive cultures died compared with those with repeat negative cultures, 6/23 (26%) vs. 6/81 (7%), respectively (P=0.02). CONCLUSION: Among infants with a positive CSF culture, a repeat positive CSF culture is common. The presence of a second positive culture is associated with increased mortality.

Full Text

Duke Authors

Cited Authors

  • Greenberg, RG; Benjamin, DK; Cohen-Wolkowiez, M; Clark, RH; Cotten, CM; Laughon, M; Smith, PB

Published Date

  • June 2011

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 425 - 429

PubMed ID

  • 21164430

Pubmed Central ID

  • PMC3103623

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/jp.2010.142


  • eng

Conference Location

  • United States