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The management of Candida infections in preterm neonates and the role of micafungin.

Publication ,  Journal Article
Manzoni, P; Benjamin, DK; Hope, W; Rizzollo, S; Del Sordo, P; Stronati, M; Jacqz-Aigrain, E; Castagnola, E; Farina, D
Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
October 2011

The burden of neonatal invasive Candida infection (ICI) has been increasing recently and identification of effective preventative and treatment strategies is a priority. In this view, the echinocandin class of antifungal agents has emerged as a suitable and promising option for treatment. These agents have overall characteristics that suitably meet the needs of neonatal patients, such as coverage against biofilms and against fluconazole-resistant strains of Candida spp, which is an issue in an epoch of increasing prophylactic use of fluconazole in the nursery. Micafungin is the only echinocandin authorized for neonatal use by the EMA, based on efficacy and PK data from neonatal populations. Although the kinetics and appropriate dosing of this agent in premature and term infants have been described in the recent years, through either neonatal studies or extrapolation form adult data, further studies are needed to better address this area. These studies should be properly designed for neonatal populations, and must better address long-term safety and the clinical outcomes related to echinocandin use in neonates.

Published In

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

DOI

EISSN

1476-4954

ISSN

1476-7058

Publication Date

October 2011

Volume

24 Suppl 2

Start / End Page

24 / 27

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • Micafungin
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Echinocandins
  • Dose-Response Relationship, Drug
  • Candidiasis
 

Citation

APA
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MLA
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Manzoni, P., Benjamin, D. K., Hope, W., Rizzollo, S., Del Sordo, P., Stronati, M., … Farina, D. (2011). The management of Candida infections in preterm neonates and the role of micafungin. The Journal of Maternal-Fetal & Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 24 Suppl 2, 24–27. https://doi.org/10.3109/14767058.2011.604929
Manzoni, Paolo, Daniel K. Benjamin, William Hope, Stefano Rizzollo, Paola Del Sordo, Mauro Stronati, Evelyne Jacqz-Aigrain, Elio Castagnola, and Daniele Farina. “The management of Candida infections in preterm neonates and the role of micafungin.The Journal of Maternal-Fetal & Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 24 Suppl 2 (October 2011): 24–27. https://doi.org/10.3109/14767058.2011.604929.
Manzoni P, Benjamin DK, Hope W, Rizzollo S, Del Sordo P, Stronati M, et al. The management of Candida infections in preterm neonates and the role of micafungin. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2011 Oct;24 Suppl 2:24–7.
Manzoni, Paolo, et al. “The management of Candida infections in preterm neonates and the role of micafungin.The Journal of Maternal-Fetal & Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 24 Suppl 2, Oct. 2011, pp. 24–27. Epmc, doi:10.3109/14767058.2011.604929.
Manzoni P, Benjamin DK, Hope W, Rizzollo S, Del Sordo P, Stronati M, Jacqz-Aigrain E, Castagnola E, Farina D. The management of Candida infections in preterm neonates and the role of micafungin. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2011 Oct;24 Suppl 2:24–27.

Published In

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

DOI

EISSN

1476-4954

ISSN

1476-7058

Publication Date

October 2011

Volume

24 Suppl 2

Start / End Page

24 / 27

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • Micafungin
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Echinocandins
  • Dose-Response Relationship, Drug
  • Candidiasis