Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
Publication
, Journal Article
Malhotra, S; Kovats, S; Zhang, W; Coggeshall, KM
Published in: J Biol Chem
December 25, 2009
The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well understood. We have identified a pathway supporting BCR internalization that begins with tyrosine phosphorylation of the adapter protein LAB. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. All these proteins contribute to (and dynamin, Vav, and Rac1/2 are required for) BCR endocytosis and presentation of antigen to T cells. This is the first description of a sequential signal transduction pathway from BCR to internalization and antigen presentation.
Duke Scholars
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Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
December 25, 2009
Volume
284
Issue
52
Start / End Page
36202 / 36212
Location
United States
Related Subject Headings
- rac1 GTP-Binding Protein
- rac GTP-Binding Proteins
- T-Lymphocytes
- Signal Transduction
- Receptors, Antigen, B-Cell
- RAC2 GTP-Binding Protein
- Proto-Oncogene Proteins c-vav
- Phosphorylation
- Neuropeptides
- Mice, Knockout
Citation
APA
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ICMJE
MLA
NLM
Malhotra, S., Kovats, S., Zhang, W., & Coggeshall, K. M. (2009). Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem, 284(52), 36202–36212. https://doi.org/10.1074/jbc.M109.040089
Malhotra, Shikha, Susan Kovats, Weiguo Zhang, and K Mark Coggeshall. “Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.” J Biol Chem 284, no. 52 (December 25, 2009): 36202–12. https://doi.org/10.1074/jbc.M109.040089.
Malhotra S, Kovats S, Zhang W, Coggeshall KM. Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem. 2009 Dec 25;284(52):36202–12.
Malhotra, Shikha, et al. “Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.” J Biol Chem, vol. 284, no. 52, Dec. 2009, pp. 36202–12. Pubmed, doi:10.1074/jbc.M109.040089.
Malhotra S, Kovats S, Zhang W, Coggeshall KM. Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem. 2009 Dec 25;284(52):36202–36212.
Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
December 25, 2009
Volume
284
Issue
52
Start / End Page
36202 / 36212
Location
United States
Related Subject Headings
- rac1 GTP-Binding Protein
- rac GTP-Binding Proteins
- T-Lymphocytes
- Signal Transduction
- Receptors, Antigen, B-Cell
- RAC2 GTP-Binding Protein
- Proto-Oncogene Proteins c-vav
- Phosphorylation
- Neuropeptides
- Mice, Knockout