Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.


Journal Article

The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well understood. We have identified a pathway supporting BCR internalization that begins with tyrosine phosphorylation of the adapter protein LAB. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. All these proteins contribute to (and dynamin, Vav, and Rac1/2 are required for) BCR endocytosis and presentation of antigen to T cells. This is the first description of a sequential signal transduction pathway from BCR to internalization and antigen presentation.

Full Text

Duke Authors

Cited Authors

  • Malhotra, S; Kovats, S; Zhang, W; Coggeshall, KM

Published Date

  • December 25, 2009

Published In

Volume / Issue

  • 284 / 52

Start / End Page

  • 36202 - 36212

PubMed ID

  • 19858206

Pubmed Central ID

  • 19858206

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

Digital Object Identifier (DOI)

  • 10.1074/jbc.M109.040089


  • eng

Conference Location

  • United States