Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVE: To develop widely acceptable preliminary criteria of global flare for childhood-onset systemic lupus erythematosus (cSLE). METHODS: Pediatric rheumatologists (n = 138) rated a total of 358 unique patient profiles with information about the cSLE flare descriptors from 2 consecutive visits: patient global assessment of well-being, physician global assessment of disease activity (MD-global), health-related quality of life, anti-double-stranded DNA antibodies, disease activity index scores, protein:creatinine (P:C) ratio, complement levels, and erythrocyte sedimentation rate (ESR). Based on 2,996 rater responses about the course of cSLE (baseline versus followup), the accuracy (sensitivity, specificity, and area under the receiver operating characteristic curve) of candidate flare criteria was assessed. An international consensus conference was held to rank these candidate flare criteria as per the American College of Rheumatology recommendations for the development and validation of criteria sets. RESULTS: The highest-ranked candidate criteria considered absolute changes (Δ) of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) or British Isles Lupus Assessment Group (BILAG), MD-global, P:C ratio, and ESR; flare scores can be calculated (0.5 × ΔSLEDAI + 0.45 × ΔP:C ratio + 0.5 × ΔMD-global + 0.02 × ΔESR), where values of ≥1.04 are reflective of a flare. Similarly, BILAG-based flare scores (0.4 × ΔBILAG + 0.65 × ΔP:C ratio + 0.5 × ΔMD-global + 0.02 × ΔESR) of ≥1.15 were diagnostic of a flare. Flare scores increased with flare severity. CONCLUSION: Consensus has been reached on preliminary criteria for global flares in cSLE. Further validation studies are needed to confirm the usefulness of the cSLE flare criteria in research and for clinical care.

Full Text

Duke Authors

Cited Authors

  • Brunner, HI; Mina, R; Pilkington, C; Beresford, MW; Reiff, A; Levy, DM; Tucker, LB; Eberhard, BA; Ravelli, A; Schanberg, LE; Saad-Magalhaes, C; Higgins, GC; Onel, K; Singer, NG; von Scheven, E; Itert, L; Klein-Gitelman, MS; Punaro, M; Ying, J; Giannini, EH

Published Date

  • September 2011

Published In

Volume / Issue

  • 63 / 9

Start / End Page

  • 1213 - 1223

PubMed ID

  • 21618452

Pubmed Central ID

  • PMC3167979

Electronic International Standard Serial Number (EISSN)

  • 2151-4658

Digital Object Identifier (DOI)

  • 10.1002/acr.20507


  • eng

Conference Location

  • United States