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Thymic microenvironment reconstitution after postnatal human thymus transplantation.

Publication ,  Journal Article
Li, B; Li, J; Devlin, BH; Markert, ML
Published in: Clin Immunol
September 2011

A functional thymus develops after cultured thymus tissue is transplanted into subjects with complete DiGeorge anomaly. To gain insight into how the process occurs, 7 post-transplantation thymus biopsy tissues were evaluated. In 5 of 7 biopsies, the thymus appeared to be predominantly cortex with thymocytes expressing cortical markers. Unexpectedly, the epithelium expressed both cortical [cortical dendritic reticulum antigen 2 (CDR2)] and medullary [cytokeratin (CK) 14] markers. Early medullary development was suggested by epithelial cell adhesion molecule (EpCAM) reactivity in small areas of biopsies. Two other biopsies had distinct mature cortex and medulla with normal restriction of CK14 to the medulla and subcapsular cortex, and of CDR2 to cortex. These data are consistent with a model in which thymic epithelium contains CK14+ "progenitor epithelial cells". After transplantation these cells proliferate as CK14+CDR2+ thymic epithelial cells that are associated with cortical thymocytes. Later these cells differentiate into distinct cortical and medullary epithelia.

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Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

September 2011

Volume

140

Issue

3

Start / End Page

244 / 259

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Stem Cells
  • Nerve Tissue Proteins
  • Lymphocyte Activation
  • Keratin-14
  • Infant, Newborn
  • Infant
  • Immunology
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, B., Li, J., Devlin, B. H., & Markert, M. L. (2011). Thymic microenvironment reconstitution after postnatal human thymus transplantation. Clin Immunol, 140(3), 244–259. https://doi.org/10.1016/j.clim.2011.04.004
Li, Bin, Jie Li, Blythe H. Devlin, and M Louise Markert. “Thymic microenvironment reconstitution after postnatal human thymus transplantation.Clin Immunol 140, no. 3 (September 2011): 244–59. https://doi.org/10.1016/j.clim.2011.04.004.
Li B, Li J, Devlin BH, Markert ML. Thymic microenvironment reconstitution after postnatal human thymus transplantation. Clin Immunol. 2011 Sep;140(3):244–59.
Li, Bin, et al. “Thymic microenvironment reconstitution after postnatal human thymus transplantation.Clin Immunol, vol. 140, no. 3, Sept. 2011, pp. 244–59. Pubmed, doi:10.1016/j.clim.2011.04.004.
Li B, Li J, Devlin BH, Markert ML. Thymic microenvironment reconstitution after postnatal human thymus transplantation. Clin Immunol. 2011 Sep;140(3):244–259.
Journal cover image

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

September 2011

Volume

140

Issue

3

Start / End Page

244 / 259

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Stem Cells
  • Nerve Tissue Proteins
  • Lymphocyte Activation
  • Keratin-14
  • Infant, Newborn
  • Infant
  • Immunology
  • Humans