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Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys.

Publication ,  Journal Article
Permar, SR; Rao, SS; Sun, Y; Bao, S; Buzby, AP; Kang, HH; Letvin, NL
Published in: J Infect Dis
December 15, 2007

Understanding the impact of human immunodeficiency virus (HIV) infection on the clinical manifestations and kinetics of measles virus (MV) replication in MV-vaccinated and unvaccinated individuals is important for developing successful vaccine strategies for measles eradication. To model the pathogenesis of MV infection in MV-vaccinated and unvaccinated individuals infected with HIV, previously vaccinated and unvaccinated rhesus monkeys infected with simian immunodeficiency virus (SIV) were challenged with MV and monitored for clinical, virologic, and immunologic sequelae of infection. The magnitude and duration of MV viremia were unchanged by SIV infection. Nevertheless, clinical manifestations of MV infection were altered in animals with significant CD4(+) T lymphocyte loss. Importantly, 2 of the 3 SIV-infected monkeys with high titers of vaccine-induced MV-neutralizing antibody developed clinical evidence of MV infection. Thus, in this experimental animal model, a high-titer vaccine-induced MV-neutralizing antibody response does not protect against clinical manifestations of measles in the setting of a chronic acquired immunodeficiency syndrome virus infection.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 15, 2007

Volume

196

Issue

12

Start / End Page

1784 / 1793

Location

United States

Related Subject Headings

  • Virus Replication
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Microbiology
  • Measles virus
  • Measles Vaccine
  • Measles
  • Macaca mulatta
 

Citation

APA
Chicago
ICMJE
MLA
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Permar, S. R., Rao, S. S., Sun, Y., Bao, S., Buzby, A. P., Kang, H. H., & Letvin, N. L. (2007). Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis, 196(12), 1784–1793. https://doi.org/10.1086/522967
Permar, Sallie R., Srinivas S. Rao, Yue Sun, Saran Bao, Adam P. Buzby, Helen H. Kang, and Norman L. Letvin. “Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys.J Infect Dis 196, no. 12 (December 15, 2007): 1784–93. https://doi.org/10.1086/522967.
Permar SR, Rao SS, Sun Y, Bao S, Buzby AP, Kang HH, et al. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis. 2007 Dec 15;196(12):1784–93.
Permar, Sallie R., et al. “Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys.J Infect Dis, vol. 196, no. 12, Dec. 2007, pp. 1784–93. Pubmed, doi:10.1086/522967.
Permar SR, Rao SS, Sun Y, Bao S, Buzby AP, Kang HH, Letvin NL. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis. 2007 Dec 15;196(12):1784–1793.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

December 15, 2007

Volume

196

Issue

12

Start / End Page

1784 / 1793

Location

United States

Related Subject Headings

  • Virus Replication
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Microbiology
  • Measles virus
  • Measles Vaccine
  • Measles
  • Macaca mulatta