Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection.
Journal Article (Journal Article)
Acute human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection is associated with a massive depletion of memory CD4(+) T lymphocytes in the gastrointestinal tract. To define the dynamics of the CD4(+) T lymphocyte subpopulations in breast milk during acute HIV or SIV infection, lymphocyte populations were monitored in blood and milk of 4 Mamu-A*01(+) rhesus monkeys after SIVmac251 inoculation. Strikingly, although the CD4(+) T lymphocytes in blood were depleted during the peak of viremia, the milk CD4(+) T lymphocyte counts remained unchanged, despite active virus replication in the breast milk compartment. Moreover, CD4(+) memory T lymphocytes were preserved in breast milk during acute infection. CD4(+) T lymphocytes in breast milk and other mucosal compartments of uninfected monkeys were similar in their memory phenotype, activation status, and chemokine (C-C motif) receptor 5 expression. Interestingly, the number and proportion of effector CD8(+) T lymphocytes in milk were increased during acute SIV infection, suggesting effective control of virus-mediated CD4(+) T lymphocyte destruction in the breast milk compartment.
Full Text
Duke Authors
Cited Authors
- Permar, SR; Kang, HH; Carville, A; Wilks, AB; Mansfield, KG; Rao, SS; Letvin, NL
Published Date
- January 15, 2010
Published In
Volume / Issue
- 201 / 2
Start / End Page
- 302 - 310
PubMed ID
- 20001855
Pubmed Central ID
- PMC2940712
Electronic International Standard Serial Number (EISSN)
- 1537-6613
Digital Object Identifier (DOI)
- 10.1086/649229
Language
- eng
Conference Location
- United States