Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys.

Published online

Journal Article

Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope sequences of milk SIV variants revealed groups of nearly identical viruses, indicating local virus production. However, comparison of the patterns and rates of CTL escape of blood and milk virus demonstrated only subtle differences between the compartments. These findings suggest that a substantial fraction of milk viruses are produced by locally-infected cells, but are shaped by cellular immune pressures similar to that in the blood.

Full Text

Duke Authors

Cited Authors

  • Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL

Published Date

  • February 1, 2010

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 7 -

PubMed ID

  • 20122164

Pubmed Central ID

  • 20122164

Electronic International Standard Serial Number (EISSN)

  • 1742-4690

Digital Object Identifier (DOI)

  • 10.1186/1742-4690-7-7

Language

  • eng

Conference Location

  • England