Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.

Published

Journal Article

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

Full Text

Duke Authors

Cited Authors

  • Permar, SR; Klumpp, SA; Mansfield, KG; Kim, W-K; Gorgone, DA; Lifton, MA; Williams, KC; Schmitz, JE; Reimann, KA; Axthelm, MK; Polack, FP; Griffin, DE; Letvin, NL

Published Date

  • April 2003

Published In

Volume / Issue

  • 77 / 7

Start / End Page

  • 4396 - 4400

PubMed ID

  • 12634396

Pubmed Central ID

  • 12634396

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.77.7.4396-4400.2003

Language

  • eng

Conference Location

  • United States