Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.


Journal Article (Review)

Receptor editing is a mode of immunological tolerance of B lymphocytes that involves antigen-induced B-cell receptor signaling and consequent secondary immunoglobulin light chain gene recombination. This ongoing rearrangement often changes B-cell specificity for antigen, rendering the cell non-autoreactive and sparing it from deletion. We currently believe that tolerance-induced editing is limited to early stages in B-cell development and that it is a major mechanism of tolerance, with a low-affinity threshold and the potential to take place in virtually every developing B cell. The present review highlights the contributions from our laboratory over several years to elucidate these features.

Full Text

Duke Authors

Cited Authors

  • Aït-Azzouzene, D; Skog, P; Retter, M; Kouskoff, V; Hertz, M; Lang, J; Kench, J; Chumley, M; Melamed, D; Sudaria, J; Gavin, A; Martensson, A; Verkoczy, L; Duong, B; Vela, J; Nemazee, D; Alfonso, C

Published Date

  • February 2004

Published In

Volume / Issue

  • 197 /

Start / End Page

  • 219 - 230

PubMed ID

  • 14962198

Pubmed Central ID

  • 14962198

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.0105-2896.2004.0106.x


  • eng

Conference Location

  • England