Antibody polyspecificity and neutralization of HIV-1: a hypothesis.

Journal Article (Journal Article;Review)

HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the conserved HIV-1 envelope trimer neutralizing epitopes are not routinely made may be down-regulation of some specificities of anti-HIV-1 antibody producing B cells by host B cell tolerance mechanisms.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM

Published Date

  • 2005

Published In

Volume / Issue

  • 14 / 3-4

Start / End Page

  • 59 - 67

PubMed ID

  • 16720975

Pubmed Central ID

  • PMC2673565

International Standard Serial Number (ISSN)

  • 1093-2607


  • eng

Conference Location

  • Netherlands