Antibody polyspecificity and neutralization of HIV-1: a hypothesis.
Journal Article (Review)
HIV-1 has evolved many ways to evade protective host immune responses, thus creating a number of problems for HIV vaccine developers. In particular, durable, broadly specific neutralizing antibodies to HIV-1 have proved difficult to induce with current HIV-1 vaccine candidates. The recent observation that some broadly neutralizing anti-HIV-1 envelope monoclonal antibodies have polyspecific reactivities to host antigens have raised the hypothesis that one reason antibodies against some of the conserved HIV-1 envelope trimer neutralizing epitopes are not routinely made may be down-regulation of some specificities of anti-HIV-1 antibody producing B cells by host B cell tolerance mechanisms.
Full Text
Duke Authors
Cited Authors
- Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM
Published Date
- 2005
Published In
Volume / Issue
- 14 / 3-4
Start / End Page
- 59 - 67
PubMed ID
- 16720975
Pubmed Central ID
- 16720975
International Standard Serial Number (ISSN)
- 1093-2607
Language
- eng
Conference Location
- Netherlands