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Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens.

Publication ,  Journal Article
de la Fuente, SG; Manson, RJ; Ludwig, KA; Mantyh, CR
Published in: J Gastrointest Surg
February 2009

PURPOSE: The purpose of this study was to compare the number of lymph nodes retrieved following proctectomy for rectal cancer in patients either receiving no neoadjuvant therapy versus those treated with standard preoperative chemoradiation. METHODS: A retrospective review was performed of all consecutive patients that underwent proctectomy for rectal cancer from 1997-2006. Specimens from patients that received neoadjuvant therapy were compared to patients that did not receive preoperative chemoradiation. RESULTS: Of a total of 286 patients, 188 received neoadjuvant therapy and 88 did not. More patients with stage II or higher cancers received neoadjuvant therapy. Overall, fewer neoadjuvant patients underwent an anastomotic procedure than the no neoadjuvant group (17% vs. 7% APR). Significantly fewer total lymph nodes were retrieved in the neoadjuvant therapy patients compared to those who did not receive preoperatively therapy (Neo 14.6 +/- 0.6 vs. No-Neo 17.2 +/- 1.1, p < 0.029). CONCLUSIONS: Standard neoadjuvant therapy significantly decreases the number of lymph nodes retrieved following proctectomy for patients with rectal cancers. Quality initiatives or performance measures evaluating lymph node harvest following proctectomy should reflect the use of preoperative chemoradiation.

Duke Scholars

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

February 2009

Volume

13

Issue

2

Start / End Page

269 / 274

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Rectal Neoplasms
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lymph Node Excision
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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de la Fuente, S. G., Manson, R. J., Ludwig, K. A., & Mantyh, C. R. (2009). Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens. J Gastrointest Surg, 13(2), 269–274. https://doi.org/10.1007/s11605-008-0717-2
Fuente, Sebastian G. de la, Roberto J. Manson, Kirk A. Ludwig, and Christopher R. Mantyh. “Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens.J Gastrointest Surg 13, no. 2 (February 2009): 269–74. https://doi.org/10.1007/s11605-008-0717-2.
de la Fuente SG, Manson RJ, Ludwig KA, Mantyh CR. Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens. J Gastrointest Surg. 2009 Feb;13(2):269–74.
de la Fuente, Sebastian G., et al. “Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens.J Gastrointest Surg, vol. 13, no. 2, Feb. 2009, pp. 269–74. Pubmed, doi:10.1007/s11605-008-0717-2.
de la Fuente SG, Manson RJ, Ludwig KA, Mantyh CR. Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens. J Gastrointest Surg. 2009 Feb;13(2):269–274.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

February 2009

Volume

13

Issue

2

Start / End Page

269 / 274

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Rectal Neoplasms
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lymph Node Excision
  • Humans
  • Female