Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.

Published

Journal Article

The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.

Full Text

Duke Authors

Cited Authors

  • Nicely, NI; Dennison, SM; Spicer, L; Scearce, RM; Kelsoe, G; Ueda, Y; Chen, H; Liao, H-X; Alam, SM; Haynes, BF

Published Date

  • December 2010

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • 1492 - 1494

PubMed ID

  • 21076400

Pubmed Central ID

  • 21076400

Electronic International Standard Serial Number (EISSN)

  • 1545-9985

International Standard Serial Number (ISSN)

  • 1545-9993

Digital Object Identifier (DOI)

  • 10.1038/nsmb.1944

Language

  • eng