A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Yoon, W; Ma, B-J; Fellay, J; Huang, W; Xia, S-M; Zhang, R; Shianna, KV; Liao, H-X; Haynes, BF; Goldstein, DB; NIAID Center for HIV/AIDS Vaccine Immunology,
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