A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.

Journal Article (Journal Article)

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.

Full Text

Duke Authors

Cited Authors

  • Yoon, W; Ma, B-J; Fellay, J; Huang, W; Xia, S-M; Zhang, R; Shianna, KV; Liao, H-X; Haynes, BF; Goldstein, DB; NIAID Center for HIV/AIDS Vaccine Immunology,

Published Date

  • January 2, 2010

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 155 - 157

PubMed ID

  • 19935381

Pubmed Central ID

  • PMC3652654

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

Digital Object Identifier (DOI)

  • 10.1097/QAD.0b013e32833202f5


  • eng

Conference Location

  • England