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[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma.

Publication ,  Journal Article
Gururangan, S; Hwang, E; Herndon, JE; Fuchs, H; George, T; Coleman, RE
Published in: Neurosurgery
December 2004

OBJECTIVE: We evaluated the [(18)F]fluorodeoxyglucose (FDG) accumulation during positron emission tomography (PET) in patients with medulloblastoma and examined the relationship of intensity of uptake with patient outcome after the initial scan. METHODS: Magnetic resonance imaging and FDG-PET scans of brain and spine were used to assess FDG uptake by visual grade (qualitative analysis) and metabolic activity ratios (T(max)/G(mean) and T(max)/W(mean)). Patients were divided into two groups based on either confirmation of tumor by biopsy and/or death resulting from progressive disease after the initial FDG-PET scan (Group A) or no intervention for the suspected lesion shown on magnetic resonance imaging after the initial FDG-PET scan but currently alive without evidence of disease (Group B). RESULTS: Twenty-two patients with either recurrent (n = 21) or newly diagnosed (n = 1) medulloblastoma underwent brain (n = 18) or whole-body (n = 4) FDG-PET scans after magnetic resonance imaging evidence of suspected tumor. The median qualitative analysis was 3 (range, 0-4) in 17 Group A patients compared with 0 (range, 0-1) in 5 Group B patients (P = 0.0003). The mean T(max)/G(mean) and T(max)/W(mean) ratios for 16 Group A patients were 1.3 (range, 0.1-3.8) and 2.10 (range, 0.4-5.2), respectively, compared with 0.80 (range, 0.20-1.5) and 1.3 (range, 0.5-1.9) in 5 Group B patients (P = 0.2 for both parameters, not significant). There was a significant negative correlation between increased FDG uptake and survival. Higher qualitative analysis and T(max)/W(mean) were associated with significantly poorer 2-year overall survival after the initial scan (71% versus 15% for qualitative analysis grade of <3 versus > or =3, P = 0.001; 46% versus 0% for T(max)/W(mean) < or =2.5 versus >2.5, P = 0.004). CONCLUSION: Increased FDG uptake is observed in medulloblastoma and is correlated negatively with survival.

Duke Scholars

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

December 2004

Volume

55

Issue

6

Start / End Page

1280 / 1288

Location

United States

Related Subject Headings

  • Whole-Body Counting
  • Treatment Outcome
  • Survival Rate
  • Qualitative Research
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Medulloblastoma
  • Male
  • Humans
  • Fluorodeoxyglucose F18
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gururangan, S., Hwang, E., Herndon, J. E., Fuchs, H., George, T., & Coleman, R. E. (2004). [18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. Neurosurgery, 55(6), 1280–1288. https://doi.org/10.1227/01.neu.0000143027.41632.2b
Gururangan, Sridharan, Eugene Hwang, James E. Herndon, Herbert Fuchs, Timothy George, and R Edward Coleman. “[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma.Neurosurgery 55, no. 6 (December 2004): 1280–88. https://doi.org/10.1227/01.neu.0000143027.41632.2b.
Gururangan S, Hwang E, Herndon JE, Fuchs H, George T, Coleman RE. [18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. Neurosurgery. 2004 Dec;55(6):1280–8.
Gururangan, Sridharan, et al. “[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma.Neurosurgery, vol. 55, no. 6, Dec. 2004, pp. 1280–88. Pubmed, doi:10.1227/01.neu.0000143027.41632.2b.
Gururangan S, Hwang E, Herndon JE, Fuchs H, George T, Coleman RE. [18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. Neurosurgery. 2004 Dec;55(6):1280–1288.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

December 2004

Volume

55

Issue

6

Start / End Page

1280 / 1288

Location

United States

Related Subject Headings

  • Whole-Body Counting
  • Treatment Outcome
  • Survival Rate
  • Qualitative Research
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Medulloblastoma
  • Male
  • Humans
  • Fluorodeoxyglucose F18