[Psychiatric and behavioral aspects of cardiovascular disease: epidemiology, mechanisms, and treatment].

Journal Article (English Abstract;Journal Article;Review)

Psychosocial and behavioral factors, including mood (depression, anxiety, anger, and stress), personality (Type A, Type D, and hostility), and social support, are associated with both the development and progression of cardiovascular disease. "Negative" emotions have been associated with increased rates of cardiovascular death and recurrent cardiac events, although the mechanisms responsible for this association remain unclear. A number of pathophysiological mechanisms have been proposed to explain these relationships, including hypothalamic-pituitary-adrenal axis dysregulation, platelet activation, and inflammation. Behavioral factors also have been implicated, such as nonadherence to prescribed medical therapies and physical inactivity. Several randomized trials of patients with cardiovascular disease have examined the impact of pharmacologic and behavioral treatments on hard cardiovascular disease events as well as on cardiovascular disease biomarkers of risk. Although psychological treatments generally have been shown to improve quality of life and psychological functioning among cardiac patients, the benefit of psychological interventions with respect to improving clinical outcomes has not been conclusively demonstrated.

Full Text

Duke Authors

Cited Authors

  • Smith, PJ; Blumenthal, JA

Published Date

  • October 2011

Published In

Volume / Issue

  • 64 / 10

Start / End Page

  • 924 - 933

PubMed ID

  • 21889253

Electronic International Standard Serial Number (EISSN)

  • 1579-2242

Digital Object Identifier (DOI)

  • 10.1016/j.recesp.2011.06.003


  • spa

Conference Location

  • Spain