Skip to main content

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

Publication ,  Journal Article
Dong, Y; Du, X; Ye, J; Han, M; Xu, T; Zhuang, Y; Tao, W
Published in: J Immunol
September 15, 2009

The MST1 kinase was recently identified as playing an essential role in the promotion of lymphocyte polarization and adhesion stimulated by chemokines and TCR signaling. However, the physiological relevance of the Mst1 pathway in thymocyte development is not completely understood. In this study, we analyzed the effect of Mst1 disruption on thymocyte development and migration. Mst1-deficient (Mst1(-/-)) mice displayed an accumulation of mature thymocytes in the thymus, a dramatic reduction of lymphocytes in blood and peripheral lymphoid tissues, and a decrease of homing ability to peripheral lymph nodes. Mst1(-/-) thymocytes were impaired in chemotactic response to chemokines, such as CCL19, but not to sphingosine-1-phosphate. Further analyses of Mst1(-/-) mice revealed a severe impairment in the egress of mature T cells from the thymus. T lineage-specific knockout of the Mst1 gene demonstrates a cell-intrinsic role for Mst1 in regulating T cell development. Our study indicates that Mst1 is crucial in controlling lymphocyte chemotaxis and thymocyte emigration.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

September 15, 2009

Volume

183

Issue

6

Start / End Page

3865 / 3872

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Proto-Oncogene Proteins
  • Mice, Knockout
  • Mice
  • Lymph Nodes
  • Immunology
  • Hepatocyte Growth Factor
  • Chemotaxis
  • Chemokines
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dong, Y., Du, X., Ye, J., Han, M., Xu, T., Zhuang, Y., & Tao, W. (2009). A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol, 183(6), 3865–3872. https://doi.org/10.4049/jimmunol.0900678
Dong, Yongli, Xingrong Du, Jian Ye, Min Han, Tian Xu, Yuan Zhuang, and Wufan Tao. “A cell-intrinsic role for Mst1 in regulating thymocyte egress.J Immunol 183, no. 6 (September 15, 2009): 3865–72. https://doi.org/10.4049/jimmunol.0900678.
Dong Y, Du X, Ye J, Han M, Xu T, Zhuang Y, et al. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol. 2009 Sep 15;183(6):3865–72.
Dong, Yongli, et al. “A cell-intrinsic role for Mst1 in regulating thymocyte egress.J Immunol, vol. 183, no. 6, Sept. 2009, pp. 3865–72. Pubmed, doi:10.4049/jimmunol.0900678.
Dong Y, Du X, Ye J, Han M, Xu T, Zhuang Y, Tao W. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol. 2009 Sep 15;183(6):3865–3872.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

September 15, 2009

Volume

183

Issue

6

Start / End Page

3865 / 3872

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Proto-Oncogene Proteins
  • Mice, Knockout
  • Mice
  • Lymph Nodes
  • Immunology
  • Hepatocyte Growth Factor
  • Chemotaxis
  • Chemokines