Arthritis syndromes associated with human T cell lymphotropic virus type I infection.

Journal Article (Journal Article;Review)

Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.

Full Text

Duke Authors

Cited Authors

  • McCallum, RM; Patel, DD; Moore, JO; Haynes, BF

Published Date

  • January 1997

Published In

Volume / Issue

  • 81 / 1

Start / End Page

  • 261 - 276

PubMed ID

  • 9012764

International Standard Serial Number (ISSN)

  • 0025-7125

Digital Object Identifier (DOI)

  • 10.1016/s0025-7125(05)70514-9


  • eng

Conference Location

  • United States