Arthritis syndromes associated with human T cell lymphotropic virus type I infection.
Journal Article (Journal Article;Review)
Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.
- McCallum, RM; Patel, DD; Moore, JO; Haynes, BF
- January 1997
Volume / Issue
- 81 / 1
Start / End Page
- 261 - 276
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States