Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.
Publication
, Journal Article
Hart, MK; Weinhold, KJ; Scearce, RM; Washburn, EM; Clark, CA; Palker, TJ; Haynes, BF
Published in: Proc Natl Acad Sci U S A
November 1, 1991
The generation of antiviral cytotoxic T lymphocytes (CTLs) is a critical component of the immune response to viral infections. A safe and nontoxic vaccine for AIDS would optimally use a carrier-free synthetic peptide immunogen containing only components of HIV necessary for induction of protective immune responses. We report that hybrid synthetic peptides containing either a HIV envelope gp120 T-cell determinant (T1) or the envelope gp41 fusion domain (F) N-terminal to HIV CTL determinants are capable of priming murine CD8+, major histocompatibility complex class I-restricted anti-HIV CTLs in vivo. These data demonstrate that carrier-free, nonderivatized synthetic peptides can be used in vivo to induce anti-HIV CTL responses.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1, 1991
Volume
88
Issue
21
Start / End Page
9448 / 9452
Location
United States
Related Subject Headings
- T-Lymphocytes, Cytotoxic
- Peptides
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Major Histocompatibility Complex
- Immunologic Memory
- HIV-1
- HIV Envelope Protein gp120
Citation
APA
Chicago
ICMJE
MLA
NLM
Hart, M. K., Weinhold, K. J., Scearce, R. M., Washburn, E. M., Clark, C. A., Palker, T. J., & Haynes, B. F. (1991). Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides. Proc Natl Acad Sci U S A, 88(21), 9448–9452. https://doi.org/10.1073/pnas.88.21.9448
Hart, M. K., K. J. Weinhold, R. M. Scearce, E. M. Washburn, C. A. Clark, T. J. Palker, and B. F. Haynes. “Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.” Proc Natl Acad Sci U S A 88, no. 21 (November 1, 1991): 9448–52. https://doi.org/10.1073/pnas.88.21.9448.
Hart MK, Weinhold KJ, Scearce RM, Washburn EM, Clark CA, Palker TJ, et al. Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9448–52.
Hart, M. K., et al. “Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.” Proc Natl Acad Sci U S A, vol. 88, no. 21, Nov. 1991, pp. 9448–52. Pubmed, doi:10.1073/pnas.88.21.9448.
Hart MK, Weinhold KJ, Scearce RM, Washburn EM, Clark CA, Palker TJ, Haynes BF. Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9448–9452.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1, 1991
Volume
88
Issue
21
Start / End Page
9448 / 9452
Location
United States
Related Subject Headings
- T-Lymphocytes, Cytotoxic
- Peptides
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Major Histocompatibility Complex
- Immunologic Memory
- HIV-1
- HIV Envelope Protein gp120