Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes.

Journal Article (Journal Article)

The present study has demonstrated that the Con A-activated cell-mediated autologous mixed lymphocyte reaction (MLR) is not associated with the generation of cytotoxic effector cells that kill autologous targets. Thus, the suppression of antibody production of PWM stimulated lymphocytes by autologous Con A-activated suppressor cells cannot be explained by detectable cytotoxicity. We have further demonstrated that the stimulator cell in this system is a nonadherent non-T cell.

Full Text

Duke Authors

Cited Authors

  • Katz, P; Haynes, BF; Fauci, AS

Published Date

  • November 1, 1978

Published In

Volume / Issue

  • 121 / 5

Start / End Page

  • 1998 - 2001

PubMed ID

  • 152333

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng

Conference Location

  • United States