HIV vaccines: where we are and where we are going.


Journal Article (Review)

As the HIV-1 epidemic continues to spread world wide, the need for an effective vaccine remains urgent. Efforts to develop such a vaccine have been hampered by three main factors: (a) the extraordinary ability of the virus to mutate; (b) inability of most known specificities of anti-HIV antibodies to neutralise HIV primary isolates consistently; and (c) lack of understanding of the correlates of protective immunity to HIV infection. In view of the complex biology of HIV-host interactions, the most fruitful avenue may be development of multivalent HIV immunogens tailored to HIV isolates in specific geographical locations.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF

Published Date

  • October 1996

Published In

Volume / Issue

  • 348 / 9032

Start / End Page

  • 933 - 937

PubMed ID

  • 8843815

Pubmed Central ID

  • 8843815

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(96)09339-7


  • eng