Role of adhesion molecules in the pathogenesis of rheumatoid arthritis.

Published

Journal Article (Review)

The pathogenesis of rheumatoid arthritis centers on as yet unknown initiating events in the synovium that result in synovial vessel proliferation, and upregulation of endothelial cell ligands for leukocyte adhesion molecules. Ligation of adhesion molecules on synovial microenvironment cells and immune cells probably regulates synovial and immune cell inflammatory cytokine production. Interruption of adhesion molecule function and interruption of inflammatory cytokine production are promising new sites of therapeutic inhibition of synovial inflammation.

Full Text

Duke Authors

Cited Authors

  • Liao, HX; Haynes, BF

Published Date

  • August 1995

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 715 - 740

PubMed ID

  • 8619096

Pubmed Central ID

  • 8619096

International Standard Serial Number (ISSN)

  • 0889-857X

Language

  • eng

Conference Location

  • United States