Role of adhesion molecules in the pathogenesis of rheumatoid arthritis.
Publication
, Journal Article
Liao, HX; Haynes, BF
Published in: Rheum Dis Clin North Am
August 1995
The pathogenesis of rheumatoid arthritis centers on as yet unknown initiating events in the synovium that result in synovial vessel proliferation, and upregulation of endothelial cell ligands for leukocyte adhesion molecules. Ligation of adhesion molecules on synovial microenvironment cells and immune cells probably regulates synovial and immune cell inflammatory cytokine production. Interruption of adhesion molecule function and interruption of inflammatory cytokine production are promising new sites of therapeutic inhibition of synovial inflammation.
Duke Scholars
Published In
Rheum Dis Clin North Am
ISSN
0889-857X
Publication Date
August 1995
Volume
21
Issue
3
Start / End Page
715 / 740
Location
United States
Related Subject Headings
- Synovial Membrane
- Selectins
- Leukocytes
- Integrins
- Hyaluronan Receptors
- Humans
- Cytokines
- Cell Movement
- Cell Adhesion Molecules
- Arthritis, Rheumatoid
Citation
APA
Chicago
ICMJE
MLA
NLM
Liao, H. X., & Haynes, B. F. (1995). Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am, 21(3), 715–740.
Liao, H. X., and B. F. Haynes. “Role of adhesion molecules in the pathogenesis of rheumatoid arthritis.” Rheum Dis Clin North Am 21, no. 3 (August 1995): 715–40.
Liao HX, Haynes BF. Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am. 1995 Aug;21(3):715–40.
Liao, H. X., and B. F. Haynes. “Role of adhesion molecules in the pathogenesis of rheumatoid arthritis.” Rheum Dis Clin North Am, vol. 21, no. 3, Aug. 1995, pp. 715–40.
Liao HX, Haynes BF. Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am. 1995 Aug;21(3):715–740.
Published In
Rheum Dis Clin North Am
ISSN
0889-857X
Publication Date
August 1995
Volume
21
Issue
3
Start / End Page
715 / 740
Location
United States
Related Subject Headings
- Synovial Membrane
- Selectins
- Leukocytes
- Integrins
- Hyaluronan Receptors
- Humans
- Cytokines
- Cell Movement
- Cell Adhesion Molecules
- Arthritis, Rheumatoid