Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.

Journal Article (Journal Article)

Using a monoclonal antibody (A2B5), which binds to GQ ganglioside, and tetanus toxin, which binds to GD and GT gangliosides, distinct regions of human and rodent thymic epithelial cells have been identified. The lymphoid elements of the thymus do not bind A2B5 or tetanus toxin. The A2B5 and tetanus toxin-binding cells form a network of thymic epithelial cells throughout the thymic subcapsular cortex and thymic medulla and contain thymopoietin and thymosin alpha-1.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Shimizu, K; Eisenbarth, GS

Published Date

  • January 1983

Published In

Volume / Issue

  • 71 / 1

Start / End Page

  • 9 - 14

PubMed ID

  • 6336763

Pubmed Central ID

  • PMC436832

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci110755

Language

  • eng

Conference Location

  • United States