Changes in thymic function with age and during the treatment of HIV infection.

Published

Journal Article

The thymus represents the major site of the production and generation of T cells expressing alphabeta-type T-cell antigen receptors. Age-related involution may affect the ability of the thymus to reconstitute T cells expressing CD4 cell-surface antigens that are lost during HIV infection; this effect has been seen after chemotherapy and bone-marrow transplantation. Adult HIV-infected patients treated with highly active antiretroviral therapy (HAART) show a progressive increase in their number of naive CD4-positive T cells. These cells could arise through expansion of existing naive T cells in the periphery or through thymic production of new naive T cells. Here we quantify thymic output by measuring the excisional DNA products of TCR-gene rearrangement. We find that, although thymic function declines with age, substantial output is maintained into late adulthood. HIV infection leads to a decrease in thymic function that can be measured in the peripheral blood and lymphoid tissues. In adults treated with HAART, there is a rapid and sustained increase in thymic output in most subjects. These results indicate that the adult thymus can contribute to immune reconstitution following HAART.

Full Text

Duke Authors

Cited Authors

  • Douek, DC; McFarland, RD; Keiser, PH; Gage, EA; Massey, JM; Haynes, BF; Polis, MA; Haase, AT; Feinberg, MB; Sullivan, JL; Jamieson, BD; Zack, JA; Picker, LJ; Koup, RA

Published Date

  • December 1998

Published In

Volume / Issue

  • 396 / 6712

Start / End Page

  • 690 - 695

PubMed ID

  • 9872319

Pubmed Central ID

  • 9872319

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/25374

Language

  • eng