Pathogenic mechanisms of vessel damage in vasculitis syndromes.

Journal Article (Journal Article;Review)

The pathogenesis of vasculitis syndromes is via a diverse array of mechanisms that disrupt vessel integrity and produce clinical signs and symptoms of tissue ischemia. In many patients with vasculitis, it is not possible to directly classify the syndrome according to a particular schema, and attempts to define the pathogenic process mediating vessel damage by biopsy and laboratory tests may be useful to guide therapy. The continued use of new techniques to probe immune cell types and cytokines in vasculitis lesional tissues will further clarify molecular mechanisms of vascular damage, and it is hoped that they will lead to new and more effective therapeutic strategies targeted at the vasculitis syndromes.

Full Text

Duke Authors

Cited Authors

  • Sundy, JS; Haynes, BF

Published Date

  • November 1995

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 861 - 881

PubMed ID

  • 8592741

International Standard Serial Number (ISSN)

  • 0889-857X


  • eng

Conference Location

  • United States