Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies.


Journal Article

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.

Full Text

Duke Authors

Cited Authors

  • Vu, HM; Myers, D; de Lorimier, R; Matthews, TJ; Moody, MA; Heinly, C; Torres, JV; Haynes, BF; Spicer, L

Published Date

  • January 1999

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 746 - 750

PubMed ID

  • 9847381

Pubmed Central ID

  • 9847381

International Standard Serial Number (ISSN)

  • 0022-538X


  • eng

Conference Location

  • United States