Cell adhesion molecules involved in intrathymic T cell development.

Journal Article (Journal Article;Review)

During stem cell migration to the thymus, intrathymic maturation of T cells, and emigration of mature T cells out of the thymus, intercellular interactions of developing T cells with a myriad of cell types are required for normal T cell development. Intercellular interactions of T cell precursors with endothelial cells, thymic epithelial cells, fibroblasts, thymic macrophages and dendritic cells are all mediated by adhesion molecules on immature T cells binding to ligands on thymic microenvironment cells. While many receptor-ligand interactions that are important in intrathymic T cell development are known, the adhesion molecules that are important for migration of T cell precursors to the thymus and for emigration of mature thymocytes from the thymus are poorly understood. An emerging concept is that select adhesion molecules at discrete stages of T cell maturation participate in and regulate the complex processes of T cell development.

Full Text

Duke Authors

Cited Authors

  • Patel, DD; Haynes, BF

Published Date

  • August 1993

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 282 - 292

PubMed ID

  • 7693023

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1006/smim.1993.1032


  • eng

Conference Location

  • England