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Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina.

Publication ,  Journal Article
Weinberg, JB; Spiegel, RA; Blazey, DL; Janssen, RS; Kaplan, JE; Robert-Guroff, M; Popovic, M; Matthews, TJ; Haynes, BF; Palker, TJ
Published in: Am J Med
July 1988

PURPOSE: Human adult T-cell leukemia-lymphoma is a malignant, proliferative disease of CD4+ lymphocytes associated with infection with human T-cell lymphotropic virus type I (HTLV-I). Following the presentation of a patient who was infected with the virus, we undertook a study of his family members and sexual contacts to see if a cluster of infected persons could be identified. CASE REPORT: A black heterosexual North Carolina native with a history of drug abuse presented with jaundice, and pancytopenia subsequently developed. He then became hypercalcemic and leukemic, with high numbers of circulating, morphologically abnormal CD4+ lymphocytes. RESULTS: As determined by radioimmunoassay and immunoblot analyses, the serum of the index case contained antibodies against core proteins (p19 and p24) of HTLV-I. When cultured in vitro with interleukin-2, the lymphocytes expressed HTLV-I specific core proteins. The virus recovered from these T cells was transmitted to cord blood T cells, which became immortalized for continuous growth in vitro, expressed HTLV-I p19 protein, and displayed characteristic C-type particles by electron microscopy. Studies of family members and sexual contacts, all of whom were black, heterosexual central North Carolina natives, revealed five of 28 whose serum had anti-HTLV-I antibodies as determined by radioimmunoassay and immunoblot. Neither the patient nor the seropositive family/contacts had antibodies against human immunodeficiency virus proteins. Four of the six people with HTLV-I infection had no history of intravenous drug abuse. Three of the five seropositive family/contacts had circulating, morphologically abnormal lymphocytes suggestive of "preleukemic" or "smoldering" human adult T-cell leukemia-lymphoma.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

July 1988

Volume

85

Issue

1

Start / End Page

51 / 58

Location

United States

Related Subject Headings

  • Space-Time Clustering
  • Sexual Partners
  • Pedigree
  • North Carolina
  • Male
  • Humans
  • General & Internal Medicine
  • Deltaretrovirus Infections
  • Deltaretrovirus
  • Antibodies, Viral
 

Citation

APA
Chicago
ICMJE
MLA
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Weinberg, J. B., Spiegel, R. A., Blazey, D. L., Janssen, R. S., Kaplan, J. E., Robert-Guroff, M., … Palker, T. J. (1988). Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina. Am J Med, 85(1), 51–58. https://doi.org/10.1016/0002-9343(88)90502-5
Weinberg, J. B., R. A. Spiegel, D. L. Blazey, R. S. Janssen, J. E. Kaplan, M. Robert-Guroff, M. Popovic, T. J. Matthews, B. F. Haynes, and T. J. Palker. “Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina.Am J Med 85, no. 1 (July 1988): 51–58. https://doi.org/10.1016/0002-9343(88)90502-5.
Weinberg JB, Spiegel RA, Blazey DL, Janssen RS, Kaplan JE, Robert-Guroff M, et al. Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina. Am J Med. 1988 Jul;85(1):51–8.
Weinberg, J. B., et al. “Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina.Am J Med, vol. 85, no. 1, July 1988, pp. 51–58. Pubmed, doi:10.1016/0002-9343(88)90502-5.
Weinberg JB, Spiegel RA, Blazey DL, Janssen RS, Kaplan JE, Robert-Guroff M, Popovic M, Matthews TJ, Haynes BF, Palker TJ. Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster in North Carolina. Am J Med. 1988 Jul;85(1):51–58.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

July 1988

Volume

85

Issue

1

Start / End Page

51 / 58

Location

United States

Related Subject Headings

  • Space-Time Clustering
  • Sexual Partners
  • Pedigree
  • North Carolina
  • Male
  • Humans
  • General & Internal Medicine
  • Deltaretrovirus Infections
  • Deltaretrovirus
  • Antibodies, Viral