Human medullary thymocyte p80 antigen and In(Lu)-related p80 antigen reside on the same protein.

Published

Journal Article

Study of human T lymphocyte differentiation antigens with monoclonal antibodies has led to the identification of two antigens shared by erythrocytes and leukocytes. The protein (p80) defined by A1G3 antibody has previously been shown to be acquired during human intrathymic T-cell maturation. The antigen defined by A3D8 antibody has been demonstrated also to reside on an 80 kd protein; expression of the A3D8 antigen on erythrocytes and a subset of leukocytes is regulated by the rare In(Lu) gene. In this study, we demonstrate that the antigens defined by the A1G3 and A3D8 antibodies reside on the same protein and represent closely related but nonidentical epitopes on the p80 molecule. Expression of the A1G3 antigen on erythrocytes and a subset of leukocytes is also down-regulated by the In(Lu) gene. The possible role of the In(Lu) gene in thymocyte differentiation is discussed.

Full Text

Duke Authors

Cited Authors

  • Telen, MJ; Shehata, H; Haynes, BF

Published Date

  • November 1986

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 311 - 324

PubMed ID

  • 2432047

Pubmed Central ID

  • 2432047

International Standard Serial Number (ISSN)

  • 0198-8859

Digital Object Identifier (DOI)

  • 10.1016/0198-8859(86)90283-1

Language

  • eng

Conference Location

  • United States