Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.

Journal Article

Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors. This anti-hsp58-reactive antigen is not demonstrable on T cells that express alpha/beta receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface of gamma/delta T cells is a approximately 77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEL-related stress proteins and gamma/delta cells that recognize groEL homologous in immunologic defense against infection and in autoimmune disease.

Full Text

Duke Authors

Cited Authors

  • Jarjour, W; Mizzen, LA; Welch, WJ; Denning, S; Shaw, M; Mimura, T; Haynes, BF; Winfield, JB

Published Date

  • December 1, 1990

Published In

Volume / Issue

  • 172 / 6

Start / End Page

  • 1857 - 1860

PubMed ID

  • 1979591

International Standard Serial Number (ISSN)

  • 0022-1007

Language

  • eng

Conference Location

  • United States