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Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.

Publication ,  Journal Article
Jarjour, W; Mizzen, LA; Welch, WJ; Denning, S; Shaw, M; Mimura, T; Haynes, BF; Winfield, JB
Published in: J Exp Med
December 1, 1990

Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors. This anti-hsp58-reactive antigen is not demonstrable on T cells that express alpha/beta receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface of gamma/delta T cells is a approximately 77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEL-related stress proteins and gamma/delta cells that recognize groEL homologous in immunologic defense against infection and in autoimmune disease.

Duke Scholars

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

December 1, 1990

Volume

172

Issue

6

Start / End Page

1857 / 1860

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Molecular Weight
  • Immunology
  • Immunoblotting
  • Humans
  • Heat-Shock Proteins
  • Fluorescent Antibody Technique
  • Escherichia coli
  • Electrophoresis, Polyacrylamide Gel
 

Citation

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Jarjour, W., Mizzen, L. A., Welch, W. J., Denning, S., Shaw, M., Mimura, T., … Winfield, J. B. (1990). Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. J Exp Med, 172(6), 1857–1860. https://doi.org/10.1084/jem.172.6.1857
Jarjour, W., L. A. Mizzen, W. J. Welch, S. Denning, M. Shaw, T. Mimura, B. F. Haynes, and J. B. Winfield. “Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.J Exp Med 172, no. 6 (December 1, 1990): 1857–60. https://doi.org/10.1084/jem.172.6.1857.
Jarjour W, Mizzen LA, Welch WJ, Denning S, Shaw M, Mimura T, et al. Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. J Exp Med. 1990 Dec 1;172(6):1857–60.
Jarjour, W., et al. “Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.J Exp Med, vol. 172, no. 6, Dec. 1990, pp. 1857–60. Pubmed, doi:10.1084/jem.172.6.1857.
Jarjour W, Mizzen LA, Welch WJ, Denning S, Shaw M, Mimura T, Haynes BF, Winfield JB. Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells. J Exp Med. 1990 Dec 1;172(6):1857–1860.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

December 1, 1990

Volume

172

Issue

6

Start / End Page

1857 / 1860

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Molecular Weight
  • Immunology
  • Immunoblotting
  • Humans
  • Heat-Shock Proteins
  • Fluorescent Antibody Technique
  • Escherichia coli
  • Electrophoresis, Polyacrylamide Gel