Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years.


Journal Article

Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90 per cent. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 +/- 0.6 years (mean +/- S.E.M.) Six of the seven with disease in remission have received no therapy for 28.3 +/- 5.7 months. Malignant lymphomas developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also percent the development of a lymphoid neoplasm.

Full Text

Duke Authors

Cited Authors

  • Fauci, AS; Haynes, BF; Costa, J; Katz, P; Wolff, SM

Published Date

  • January 14, 1982

Published In

Volume / Issue

  • 306 / 2

Start / End Page

  • 68 - 74

PubMed ID

  • 7053488

Pubmed Central ID

  • 7053488

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM198201143060203


  • eng

Conference Location

  • United States