Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.

Published

Journal Article (Review)

Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight d, together with prednisone, 1 mg/kg body weight d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (+/- 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (+/- 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.

Full Text

Duke Authors

Cited Authors

  • Fauci, AS; Haynes, BF; Katz, P; Wolff, SM

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 98 / 1

Start / End Page

  • 76 - 85

PubMed ID

  • 6336643

Pubmed Central ID

  • 6336643

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-98-1-76

Language

  • eng

Conference Location

  • United States