Thymoma: lymphoid and epithelial components mirror the phenotype of normal thymus.

Published

Journal Article

Six thymomas were studied with monoclonal and polyclonal antisera and an immunohistochemical technique to characterize the lymphocytic and epithelial components of the tumor. The T lymphocytes had characteristics of thymocytes, and cortico medullary differentiation was demonstrated within all tumors, regardless of histologic appearance. Cortical thymocytes were positive with anti-terminal deoxynucleotidyl transferase, OKT6, and OKT10, all of which failed to stain medullary thymocytes. Conversely, A1G3 stained medullary thymocytes exclusively. Epithelial cells reacted with A2B5, an antibody that identifies cells of neuroendocrine origin. Epithelial cell processes were also positive with anti-p19, a monoclonal antibody directed against the internal protein of HTLV, which also reacts with normal thymic epithelium. No correlation was found in the distribution of epithelial cells with evidence of cortical and medullary thymocyte differentiation. However, the components of the tumor mirrored the normal cellular and structural components of the thymus.

Full Text

Duke Authors

Cited Authors

  • Mokhtar, N; Hsu, SM; Lad, RP; Haynes, BF; Jaffe, ES

Published Date

  • April 1984

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 378 - 384

PubMed ID

  • 6609116

Pubmed Central ID

  • 6609116

Electronic International Standard Serial Number (EISSN)

  • 1532-8392

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/s0046-8177(84)80037-4

Language

  • eng