Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.
Journal Article (Journal Article)
We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T-cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets.
Full Text
Duke Authors
Cited Authors
- Hooks, JJ; Haynes, BF; Detrick-Hooks, B; Diehl, LF; Gerrard, TL; Fauci, AS
Published Date
- January 1, 1982
Published In
Volume / Issue
- 59 / 1
Start / End Page
- 198 - 201
PubMed ID
- 6172170
International Standard Serial Number (ISSN)
- 0006-4971
Language
- eng
Conference Location
- United States