Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.

Published

Journal Article

We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T-cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets.

Full Text

Duke Authors

Cited Authors

  • Hooks, JJ; Haynes, BF; Detrick-Hooks, B; Diehl, LF; Gerrard, TL; Fauci, AS

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 198 - 201

PubMed ID

  • 6172170

Pubmed Central ID

  • 6172170

International Standard Serial Number (ISSN)

  • 0006-4971

Language

  • eng

Conference Location

  • United States