CD6-ligand interactions: a paradigm for SRCR domain function?

Journal Article (Journal Article;Review)

The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.

Full Text

Duke Authors

Cited Authors

  • Aruffo, A; Bowen, MA; Patel, DD; Haynes, BF; Starling, GC; Gebe, JA; Bajorath, J

Published Date

  • October 1997

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 498 - 504

PubMed ID

  • 9357143

International Standard Serial Number (ISSN)

  • 0167-5699

Digital Object Identifier (DOI)

  • 10.1016/s0167-5699(97)01130-4


  • eng

Conference Location

  • England