Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development.

Journal Article (Journal Article)

Although most investigators agree that the CD4- CD8- CD3- thymocyte subset represents the most immature intrathymic T cell capable of repopulating the thymus in vivo, little is known of the earliest stages of human T-cell development. Using mAbs to hematopoietic and T-cell lineage molecules in quantitative immunofluorescence studies, new insight has been gained regarding the phenotype of human T-cell precursors before and after colonization of human thymic rudiment. In this article, Barton Haynes and colleagues discuss the sequential expression of CD7, CD4, CD8, CD3, CD2, CD1, CD45, TCR gamma delta and TCR alpha beta, and propose a model defining the stages of T-cell precursors during fetal ontogeny.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Denning, SM; Singer, KH; Kurtzberg, J

Published Date

  • March 1989

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 87 - 91

PubMed ID

  • 2472811

International Standard Serial Number (ISSN)

  • 0167-5699

Digital Object Identifier (DOI)

  • 10.1016/0167-5699(89)90232-6


  • eng

Conference Location

  • England