Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.

Journal Article

Mixed lymphocyte reaction (MLR)-activated T cells were analyzed according to the expression of various cell surface markers by the specific cytotoxic T lymphocytes (CTL) generated in the MLR. CTL were found exclusively in a population of MLR-activated T cells that lacked detectable Fc gamma R but that expressed a surface antigen recognized by the 4F2 monoclonal antibody. In contrast, CTL were found in both the Ia-positive and Ia-negative cells after MLR activation. Thus, the specific CTL generated in the allogeneic MLR can be identified and isolated by virtue of the expression of a particular cell surface marker.

Full Text

Duke Authors

Cited Authors

  • Moretta, A; Mingari, MC; Haynes, BF; Sekaly, RP; Moretta, L; Fauci, AS

Published Date

  • January 1, 1981

Published In

Volume / Issue

  • 153 / 1

Start / End Page

  • 213 - 218

PubMed ID

  • 6450261

International Standard Serial Number (ISSN)

  • 0022-1007

Language

  • eng

Conference Location

  • United States