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Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.

Publication ,  Journal Article
Gallo, RC; Salahuddin, SZ; Popovic, M; Shearer, GM; Kaplan, M; Haynes, BF; Palker, TJ; Redfield, R; Oleske, J; Safai, B
Published in: Science
May 4, 1984

Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

May 4, 1984

Volume

224

Issue

4648

Start / End Page

500 / 503

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Risk
  • RNA-Directed DNA Polymerase
  • Male
  • Interferon Type I
  • Immune Sera
  • Humans
  • Homosexuality
  • General Science & Technology
  • Female
 

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Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, G. M., Kaplan, M., Haynes, B. F., … Safai, B. (1984). Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science, 224(4648), 500–503. https://doi.org/10.1126/science.6200936
Gallo, R. C., S. Z. Salahuddin, M. Popovic, G. M. Shearer, M. Kaplan, B. F. Haynes, T. J. Palker, R. Redfield, J. Oleske, and B. Safai. “Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.Science 224, no. 4648 (May 4, 1984): 500–503. https://doi.org/10.1126/science.6200936.
Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984 May 4;224(4648):500–3.
Gallo, R. C., et al. “Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.Science, vol. 224, no. 4648, May 1984, pp. 500–03. Pubmed, doi:10.1126/science.6200936.
Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984 May 4;224(4648):500–503.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

May 4, 1984

Volume

224

Issue

4648

Start / End Page

500 / 503

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Risk
  • RNA-Directed DNA Polymerase
  • Male
  • Interferon Type I
  • Immune Sera
  • Humans
  • Homosexuality
  • General Science & Technology
  • Female