Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group.
Journal Article (Journal Article)
The selection and characterization of a cloned murine monoclonal antibody (4D12) that defines an HLA allotypic determinant is described. Antibody 4D12 immunoprecipitates HLA heavy and light chains. From studies on 4D12 reactivity with a large panel of well-characterized target cells, antibody 4D12 defines a public HLA determinant that includes specificities within but not identical to the B5 cross-reacting group. Antibody 4D12 should be useful in the study of HLA-B5--related supratypic antigens.
Full Text
Duke Authors
Cited Authors
- Haynes, BF; Reisner, EG; Hemler, ME; Strominger, JL; Eisenbarth, GS
Published Date
- July 1982
Published In
Volume / Issue
- 4 / 4
Start / End Page
- 273 - 285
PubMed ID
- 6181035
International Standard Serial Number (ISSN)
- 0198-8859
Digital Object Identifier (DOI)
- 10.1016/0198-8859(82)90001-5
Language
- eng
Conference Location
- United States