Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group.

Journal Article (Journal Article)

The selection and characterization of a cloned murine monoclonal antibody (4D12) that defines an HLA allotypic determinant is described. Antibody 4D12 immunoprecipitates HLA heavy and light chains. From studies on 4D12 reactivity with a large panel of well-characterized target cells, antibody 4D12 defines a public HLA determinant that includes specificities within but not identical to the B5 cross-reacting group. Antibody 4D12 should be useful in the study of HLA-B5--related supratypic antigens.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Reisner, EG; Hemler, ME; Strominger, JL; Eisenbarth, GS

Published Date

  • July 1982

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 273 - 285

PubMed ID

  • 6181035

International Standard Serial Number (ISSN)

  • 0198-8859

Digital Object Identifier (DOI)

  • 10.1016/0198-8859(82)90001-5


  • eng

Conference Location

  • United States