In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice.

Journal Article (Review)

The discovery of the SCID mouse mutation has been an important advance for the study of human lymphopoiesis and autoimmunity. Further work in the SCID mouse models described in this review should yield important new information related to transplantation of human hematopoietic stem cells across HLA barriers, characterization of hematopoietic development in vivo, and identification of pathogenic human T cell clones in organ-specific autoimmune diseases. If pluripotent hematopoietic stem cells and pathogenic autoimmune T cells can be defined using SCID mouse recipients, this would pave the way for development of novel strategies for bone marrow transplantation and for interventional immunotherapy of autoimmune diseases targeted at the T cell receptor (99).

Full Text

Duke Authors

Cited Authors

  • Barry, TS; Haynes, BF

Published Date

  • September 1992

Published In

Volume / Issue

  • 12 / 5

Start / End Page

  • 311 - 324

PubMed ID

  • 1358912

International Standard Serial Number (ISSN)

  • 0271-9142

Language

  • eng

Conference Location

  • Netherlands