Structure and function of the CD7 molecule.

Published

Journal Article (Review)

CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Because of lack of identification of a natural ligand and lack of a monoclonal antibody against murine CD7, the in vivo functions of CD7 have until recently remained obscure. Recent studies in CD7-deficient mice have provided new insights into CD7 function, and demonstrated key roles for CD7 in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes. This article reviews recent work on the expression, structure, and function of CD7, and discusses roles the CD7 molecule might play in T and NK cell development and function.

Full Text

Duke Authors

Cited Authors

  • Sempowski, GD; Lee, DM; Kaufman, RE; Haynes, BF

Published Date

  • January 1999

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 331 - 348

PubMed ID

  • 10530432

Pubmed Central ID

  • 10530432

International Standard Serial Number (ISSN)

  • 1040-8401

Language

  • eng