Association of the human type C retrovirus with a subset of adult T-cell cancers.
To determine whether the human T-cell lymphoma-leukemia virus (HTLV) is associated with particular cancers, patient sera were surveyed for HTLV-specific antibodies. An association was seen with aggressive cancers of mature T-cells, specifically Japanese adult T-cell leukemia (ATL) and T-cell lymphosarcoma cell leukemia (TLCL), a similar cancer of Caribbean blacks. Ninety to 100% of these patients possessed HTLV-specific antibody. Forty-seven and 20% of relatives of ATL and TLCL patients, respectively, and 12 and 4% of healthy donors from ATL and TLCL endemic areas were also antibody positive. Visceral organ involvement, hypercalcemia, and skin manifestation, features of ATL and TLCL, were often seen in other antibody-positive patients. Childhood cancers, most cutaneous T-cell and all non-T-cell leukemias and lymphomas, myeloid leukemias, Hodgkin's disease, and solid tumors were not associated with HTLV. Healthy United States donors and European patients with non-malignant diseases were antibody negative. HTLV is thus associated with a subtype of adult T-cell leukemia-lymphoma, clustered in viral endemic areas, with apparent racial and geographic predilection.
Gallo, RC; Kalyanaraman, VS; Sarngadharan, MG; Sliski, A; Vonderheid, EC; Maeda, M; Nakao, Y; Yamada, K; Ito, Y; Gutensohn, N; Murphy, S; Bunn, PA; Catovsky, D; Greaves, MF; Blayney, DW; Blattner, W; Jarrett, WF; zur Hausen, H; Seligmann, M; Brouet, JC; Haynes, BF; Jegasothy, BV; Jaffe, E; Cossman, J; Broder, S; Fisher, RI; Golde, DW; Robert-Guroff, M
Volume / Issue
Start / End Page
Pubmed Central ID
International Standard Serial Number (ISSN)