Monoclonal antibodies to a human islet cell surface glycoprotein: 4F2 and LC7-2.

Journal Article (Journal Article)

Monoclonal antibodies 4F2 and LC7-2 react with a cell surface differentiation antigen expressed by the endocrine cells of the human pancreatic islet, but not by the acinar pancreatic, ductular, vascular, or stromal connective tissue cells. Western immunoblotting procedures demonstrate the reactivity of the monoclonal antibody 4F2 with a 120 kilodalton islet cell protein in detergent-solubilized cell extracts. These two monoclonal antibodies have potential for application in many aspects of islet cell research and diabetes in general.

Full Text

Duke Authors

Cited Authors

  • Srikanta, S; Telen, M; Posillico, JT; Dolinar, R; Krisch, K; Haynes, BF; Eisenbarth, GS

Published Date

  • June 1987

Published In

Volume / Issue

  • 120 / 6

Start / End Page

  • 2240 - 2244

PubMed ID

  • 2436897

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/endo-120-6-2240


  • eng

Conference Location

  • United States